Zombie slayers Tallahassee (Woody Harrelson), Columbus (Jesse Eisenberg), Wichita (Emma Stone) and Little Rock (Abigail Breslin) have been living together as a family for the last 10 years.

When Little Rock runs away with Berkeley, a pacifist she just met, the team has to band together to bring her back. They must also face new evolved zombies, who are faster, deadlier and much more difficult to kill.

Enroute, they also meet Madison (Zoey Deutch), a silly blonde, as well as a dynamic pair of survivors— Albuquerque (Luke Wilson) and his wingman Flagstaff (Thomas Middleditch).