Having settled down in Arizona on a horse ranch, John Rambo (Sylvester Stallone) has retired, only taking part in rare voluntary rescue missions in the area. Living with him are a family friend, Maria (Adriana Barraza), and her granddaughter Gabrielle (Yvette Monreal).

However, when Gabrielle travels to Mexico to look for her runaway father, she's abducted by a sex trafficking cartel. Rambo must confront his past and unearth his ruthless combat skills to exact revenge in a final mission.

A deadly journey of vengeance, RAMBO: LAST BLOOD marks the last chapter of the legendary series.