While on a mission in space, astronaut Lucy Cola (Natalie Portman) begins to lose touch with reality. Although the crew has a lot of work to do, she can't stop herself from losing focus.

When she returns to Earth, she has trouble interacting with others, often staring into space or getting lost in her thoughts. Despite having a supportive husband (Dan Stevens), Lucy has an affair with another astronaut, Mark Goodwin (Jon Hamm). When Mark dumps her, Lucy decides to kidnap new recruit Erin Eccles (Zazie Beetz), Mark's new lover.

Based on a true story.