Brent Ryan (Nicolas Cage) is going through a mid-life crisis, while his wife, Kendall (Selma Blair) is trying to bond with their teenage daughter Carly (Anne Winters), who has grown rude and distant.

When a mass hysteria of unknown origins causes parents to turn violently on their own kids, Carly and her little brother Josh (Zackary Arthur) must try to survive a wild 24 hours.