Drive-Away Dolls follows Jamie (Margaret Qualley), an uninhibited free spirit bemoaning yet another breakup with a girlfriend, and her demure friend Marian (Geraldine Viswanathan) who desperately needs to loosen up.

In search of a fresh start, the two embark on an impromptu road trip to Tallahassee, but things quickly go awry when they accidentally take off with stolen loot that a group of inept criminals would like to get back.